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This restriction is based on the regimen used in the NINDS trials.<>83] Arterial reocclusion may follow successful recanalization with thrombolysis.<>84] Thus, there is interest in the use of an anticoagulant that may maintain arterial patency after thrombolytic therapy. The trials of intra-arterial administration of prourokinase used heparin as part of the treatment regimen, and the control group received only heparin.<>85]<>86]<>87] In the first study, both the success of recanalization and the risk of hemorrhage were increased among the patients who received the larger of the 2 doses of adjunctive heparin. Two small studies have tested the use of intravenously administered heparin after treatment with rtPA.<>88]<>89] No increase in bleeding complications has been reported. Heparin also has been given in combination with abciximab with a reasonable degree of safety.<>90] The experience with adjunctive anticoagulation is limited. 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